The Crossroads between Infection and Bone Loss

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Oliveira, TC (Author) Other; Gomes, MS (Author) ICBAS; Gomes, AC (Author) Other

Journal

Title: Microorganisms

Vol. 8

Pages: 1-18

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 3 Citations

Other information

Authenticus ID: P-00T-1KN

DOI: 10.3390/microorganisms8111765

Abstract (EN): Bone homeostasis, based on a tight balance between bone formation and bone degradation, is affected by infection. On one hand, some invading pathogens are capable of directly colonizing the bone, leading to its destruction. On the other hand, immune mediators produced in response to infection may dysregulate the deposition of mineral matrix by osteoblasts and/or the resorption of bone by osteoclasts. Therefore, bone loss pathologies may develop in response to infection, and their detection and treatment are challenging. Possible biomarkers of impaired bone metabolism during chronic infection need to be identified to improve the diagnosis and management of infection-associated osteopenia. Further understanding of the impact of infections on bone metabolism is imperative for the early detection, prevention, and/or reversion of bone loss. Here, we review the mechanisms responsible for bone loss as a direct and/or indirect consequence of infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 18