Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Catarino, MD (Author) Other; Amarante, SJ (Author) Other; Nuno Mateus (Author) FCUP; Silva, AMS (Author) Other; Cardoso, SM (Author) Other

Journal

Title: Foods

Vol. 9

Final page: 1478

Publisher: MDPI

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 37 Citations

Other information

Authenticus ID: P-00V-7J2

DOI: 10.3390/foods10071478

Abstract (EN): According to the WHO, cancer was responsible for an estimated 9.6 million deaths in 2018, making it the second global leading cause of death. The main risk factors that lead to the development of this disease include poor behavioral and dietary habits, such as tobacco use, alcohol use and lack of fruit and vegetable intake, or physical inactivity. In turn, it is well known that polyphenols are deeply implicated with the lower rates of cancer in populations that consume high levels of plant derived foods. In this field, phlorotannins have been under the spotlight in recent years since they have shown exceptional bioactive properties, with great interest for application in food and pharmaceutical industries. Among their multiple bioactive properties, phlorotannins have revealed the capacity to interfere with several biochemical mechanisms that regulate oxidative stress, inflammation and tumorigenesis, which are central aspects in the pathogenesis of cancer. This versatility and ability to act either directly or indirectly at different stages and mechanisms of cancer growth make these compounds highly appealing for the development of new therapeutical strategies to address this world scourge. The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress-inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 27