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Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates

Title
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates
Type
Article in International Scientific Journal
Year
2018
Authors
Matos, MJ
(Author)
Other
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Labao Almeida, C
(Author)
Other
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Sayers, C
(Author)
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Dada, O
(Author)
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Tacke, M
(Author)
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Bernardes, GJL
(Author)
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Journal
Vol. 24
ISSN: 0947-6539
Publisher: Wiley-Blackwell
Other information
Authenticus ID: P-00P-HEP
Abstract (EN): Targeted delivery of potent cytotoxic drugs to cancer cells minimizes systemic toxicity and several side effects. NHC*-Au-Cl has already been proven to be a potent anticancer agent. In this study, we explore a strategy based on chemoselective cysteine conjugation of NHC*-Au-Cl to albumin and trastuzumab (Thiomab LC-V205C) to potentiate drug-ligand ratio, pharmacokinetics, as well as drug efficacy and safety. This strategy is a step forward towards the use of gold-based anticancer agents as targeted therapies.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 4
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