Effects of Exercise Interventions in Graft-Versus-Host Disease Models

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Fiuza Luces, C (Author) Other; Gonzalez Murillo, A (Author) Other; Soares Miranda, L (Author) FADEUP; Palacio, JM (Author) Other; Colmenero, I (Author) Other; Casco, F (Author) Other; Melen, G (Author) Other; Moran, M (Author) Other; Lucia, A (Author) Other; Ramirez, M (Author) Other

Journal

Title: Cell Transplantation

Vol. 22

Pages: 2409-2420

ISSN: 0963-6897

Publisher: SAGE

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-008-JQZ

DOI: 10.3727/096368912x658746

Abstract (EN): Graft-versus-host-disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is associated with high morbimortality and decreased patients' physical capacity. We evaluated the effects of an 11-week moderate-intensity exercise (treadmill) training program performed after allo-HSCT in a murine acute (aGVHD) and chronic GVHD model (cGVHD). Female mice (aged 8-12 weeks) were randomly assigned to the exercise or the control group. They completed a maximal treadmill test before allo-HSCT (with donor bone marrow cells and splenocytes) and after the 11-week period, during which we evaluated clinical severity scores and survival (Kaplan-Meier method). Before allo-HSCT and at days + 21, + 52 and + 83 (upon sacrifice), we collected blood samples for immune cell reconstitution and cytokine analysis. The main results were that (i) in aGVHD, exercise improved maximal physical capacity over the 11-week period compared with pre-allo-HSCT conditions (p < 0.001 for the between-group comparison) and benefited total clinical score evolution (p = 0.05 for the group x time interaction effect), without altering immune reconstitution; (ii) in cGVHD, exercise training resulted in a lesser deterioration of physical capacity after 11 weeks (p = 0.023). Our results highlight the potential beneficial effects of exercise as coadjuvant intervention against GVHD, especially in the acute form of the disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12