Oral Lichen Planus in IBD Patients: A Paradoxical Adverse Effect of Anti-TNF-alpha Therapy

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Andrade, P (Author) Other; Lopes, S (Author) Other; Albuquerque, A (Author) Other; Osorio, F (Author) Other; Pardal, J (Author) Other; Macedo G (Author) FMUP

Journal

The Journal is awaiting validation by the Administrative Services.

Title: DIGESTIVE DISEASES AND SCIENCES

Vol. 60

Pages: 2746-2749

ISSN: 0163-2116

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00G-3MJ

DOI: 10.1007/s10620-015-3680-2

Abstract (EN): Introduction and aims The efficacy of tumor necrosis factor alpha (TNF-alpha) inhibitors in the treatment of Inflammatory Bowel Disease (IBD) is well established. Many cutaneous and mucosal lesions have been described under anti-TNF-alpha therapy, some of them being considered as paradoxical. In this series we aimed to review the cases of oral lichen planus (OLP) in IBD patients under treatment with anti-TNF-alpha agents. Methods Histologic findings from oral lesions of IBD patients treated with anti-TNF were revised. Results Three female patients with IBD developed oral lichen planus (OLP) after starting anti-TNF-alpha therapy. Other etiologies were excluded. Conclusions In light of the increasing use of TNF-alpha inhibitors the occurrence of OLP is a potentially emerging side effect, thus we recommend a careful monitoring for oral manifestations in IBD patients treated with anti-TNF-alpha agents.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4