pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Chaves, LL (Author) Other; Silveri, A (Author) Other; Vieira, ACC (Author) Other; Ferreira, DC (Author) FFUP; Cristiano, MC (Author) Other; Paolino, D (Author) Other; Di Marzio, L (Author) Other; Lima, SC (Author) Other; Salette Reis (Author) FFUP; Sarmento, B (Author) Other; Celia, C (Author) Other

Journal

Title: International Journal of Biological Macromolecules

Vol. 133

Pages: 1268-1279

ISSN: 0141-8130

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 12 Citations

Other information

Authenticus ID: P-00Q-JTA

DOI: 10.1016/j.ijbiomac.2019.04.178

Abstract (EN): Dapsone (DAP) is a bactericidal agent used in the treatment of leprosy, caused by Mycobacterium leprae. Despite its therapeutic potential, DAP has low solubility, which results in allow therapeutic index and a high microbial resistance. Recently, new approaches were used to increase the DAP solubility. In particular, the use of interpenetrating polymer network (IPN)-hydrogels based chitosan (CS) for the controlled release of DAP provides some advantages because they can modify their swelling properties and network structures as a response to environmental stimuli. The aim of this study was to synthesize and physicochemically characterize pH-responsive chitosan/polymer hydrogels to control the release of DAP. For this reason, different combination of polymers, such as polyvinyl pyrrolidone, polyethylene glycol and hydroxypropyl methylcellulose, and concentrations of the cross linking agents (glutaraldehyde) were used and then blended to the CS. The resulting hydrogels were evaluated in terms of physicochemical and swelling properties, rheological analysis and in vitro release of DAP at different pHs (1.2-6.8). Hydrogels were further characterized by Fourier transformed infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) analysis, pH-responsive DAP-loaded hydrogels may represent the set-up for developing potential oral formulations for the treatment of leprosy caused by Mycobacterium leprae. (C) 2019 Published by Elsevier B.V.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12