Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis

• Type: Another Publication in an International Scientific Journal
• Date: 2016-11

Authors

Sousa, AM (Author) Other; Grandgenett, PM (Author) Other; David L (Author) FMUP; Raquel Almeida (Author) FCUP; Hollingsworth, MA (Author) Other; Santos-Silva F (Author) FMUP

Journal

Title: APMIS: acta pathologica, microbiologica, et immunologica Scandinavica

Vol. 124 No. 11

Pages: 913-924

ISSN: 0903-4641

Publisher: John Wiley & Sons

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 16 Citations

Other information

Authenticus ID: P-00M-8WZ

DOI: 10.1111/apm.12587

Abstract (EN): Mucin 1 (MUC1) has been described as the renaissance molecule due to the large set of functions it displays in both normal and neoplastic cells. This membrane-tethered glycoprotein is overexpressed and aberrantly glycosylated in most epithelial cancers, being involved in several processes related with malignant phenotype acquisition. With a highly polymorphic structure, both in the polypeptide and glycan counterparts, MUC1 variability has been associated with susceptibility to several diseases, including cancer. Biochemical features and biological functions have been characterized upon the full-length MUC1 protein, remaining to clarify the real impact on cell dynamics of the plethora of MUC1 isoforms. This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of MUC1 isoforms involvement in malignant phenotype.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12