Blood propofol concentrations: On demand for pharmacokinetic/ pharmacodynamics models and new measurement automatic technologies

• Type: Article in International Conference Proceedings Book
• Date: 2012

Authors

Campos, S (Author) Other; Silva, A (Author) Other; De Pinho, PG (Author) FFUP; Antunes, L (Author) Other

Conference proceedings International

Title: Proceedings of the International Workshop on Veterinary Biosignals and Biodevices, VBB 2012, in Conjunction with BIOSTEC 2012

Pages: 18-23

1st International Workshop on Veterinary Biosignals and Biodevices, VBB 2012, in Conjunction with BIOSTEC 2012

Vilamoura, Algarve, 1 February 2012 through 4 February 2012

Indexing

Scopus - 0 Citations

Other information

Authenticus ID: P-008-483

Abstract (EN): Propofol is a widespread anaesthetic agent in human medicine. It allows the practice of total intravenous anaesthesia through the use of sophisticated delivery systems due to its pharmacokinetic/pharmacodynamics properties. Three New Zealand White rabbits were anaesthetized with three different infusion rates (70, 100, 130 mg.kg -1.h -1) in a random order, during thirty minutes each. Clinical parameters as well as arterial blood samples were collected at specific time points. Rugloop II Vet software was used to storage all data and to predict the propofol concentrations during the anaesthetic period. A correlation analysis was done between real and predicted propofol concentrations, in each infusion rate. It was only observed a significant correlation between concentrations during the lower infusion rate (70 mg.kg -1.h -1). There is a lack of automatic devices and pharmacokinetic/pharmacodynamics models that allow a real-time or predicted measurement of the propofol concentrations in the patient, for veterinary medicine.

Language: English

Type (Professor's evaluation): Scientific