Prognostic Value of High-Sensitivity C-Reactive Protein in Heart Failure: A Systematic Review

• Type: Another Publication in an International Scientific Journal
• Date: 2009

Authors

Araújo JP (Author) FMUP; Lourenco, P (Author) FMUP; Azevedo A (Author) FMUP; Friões F (Author) FMUP; Rocha Goncalves, F (Author) Other; Ferreira A (Author) FMUP; Bettencourt P (Author) FMUP

Journal

Title: Journal of Cardiac Failure

Vol. 15

Pages: 256-266

ISSN: 1071-9164

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 98 Citations

Scopus - 109 Citations

Other information

Authenticus ID: P-003-M5A

DOI: 10.1016/j.cardfail.2008.10.030

Abstract (EN): Background: Several studies have suggested that high-sensitivity C-reactive protein (hsCRP) is a strong independent predictor of acute myocardial infarction and cardiovascular death. In the specific heart failure (HF) context, a low-grade inflammatory state can contribute to HF progression. Aims: To perform a systematic review on the current knowledge about low-grade inflammation, as assessed by hsCRP, in the prediction of HF in general and in high-risk populations as well as its prognostic value in established HF. Methods: We used a computerized literature search in the Medline database using the following key words: C-Reactive Protein, Heart Failure, Cardiomyopathy, Cardiac Failure, Prognosis, and Death. Articles were selected if they had measurements of hsCRP in different patient samples and reference to outcomes in terms of morbidity and mortality. Results: hsCRP is associated with incident HF in general and high-risk populations and provides prognostic information in HF patients. In almost all studies, the association of hsCRP with clinical events was independent of other baseline variables known to influence morbidity and mortality. Very different cutoffs have been proposed in each context across studies. Conclusions: The prognostic power of hsCRP, whether we consider incident HF or adverse outcomes in established HF, is consistent in different patient populations. (J Cardiac Fail 2009:15:256-266)

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11