Chlamydia trachomatis infection: implications for HPV status and cervical cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Silva, J (Author) Other; Cerqueira, F (Author) Other; Rui Medeiros (Author) ICBAS

Journal

The Journal is awaiting validation by the Administrative Services.

Title: ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Vol. 289

Pages: 715-723

ISSN: 0932-0067

Publisher: Springer Berlin Heidelberg

Indexing

ISI Web of Knowledge - 103 Citations

Scopus - 113 Citations

Other information

Authenticus ID: P-009-A6B

DOI: 10.1007/s00404-013-3122-3

Abstract (EN): Genital Chlamydia trachomatis (CT) infections have been identified as a major health problem concern. CT is associated with adverse effect on women reproduction and also associated with cervical hypertrophy and induction of squamous metaplasia, providing a possible relationship with human papillomavirus (HPV) infection. Infection by high-risk HPV types is crucial to the pathogenesis of invasive cervical cancer (ICC), but other co-variants/cofactors must be present for the development of malignancy. CT biological effect may damage the mucosal barrier, improving HPV infection, or may interfere in immune response and viral clearance supporting the persistence of HPV infection. Moreover, CT-related chronic cervical inflammation, decrease of lower genital tract antigen-presenting cells, inhibition of cell-mediated immunity, and anti-apoptotic capacity may influence the natural history of HPV infection, namely persistence progression or resolution. Although several epidemiological studies have stated a positive association involving CT and HPV-related cervical neoplastic lesions and/or cervical cancer (CC), the specific role of this bacterium in the pathogenesis of cervical neoplasia has not been completely clarified. The present review summarizes several studies on CT role in cervical cancer and suggests future research directions on HPV and CT interaction.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9