Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease

• Type: Article in International Scientific Journal
• Date: 2004

Authors

Ribeiro, R (Author) Other; Vasconcelos, A (Author) Other; Costa, S (Author) Other; Pinto, D (Author) Other; Morais, A (Author) Other; Oliveira, J (Author) Other; Lobo, F (Author) Other; Lopes, C (Author) ICBAS; Medeiros, R (Author) ICBAS

Journal

Title: Prostate

Vol. 59

Pages: 268-274

ISSN: 0270-4137

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 82 Citations

Scopus - 89 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-ACT

DOI: 10.1002/pros.20004

Abstract (EN): BACKGROUND. Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele). METHODS. We evaluated DNA samples from 268 (536 alleles) unrelated individuals, 118 healthy controls (HCs) and 150 prostate cancer (PC) patients, for leptin gene (LEP) locus -2548 genotypes. RESULTS. We found an overrepresentation of the A-allele in PC patients and that there is a significantly higher risk for PC among A carriers (OR = 1.60; confidence interval (CI), 1.13-2.28, P = 0.008). Linear trend analysis showed that quantitative increase of A-allele presence was associated with significantly higher risk for PC (P = 0.003) in heterozygous (OR = 2.11; CI, 1.20-3.71) and homozygous (OR = 2.93; Cl, 1.27-6.75) genotypes. Furthermore, the AA and AG genotypes represent significantly higher risk (OR = 4.67; CI, 1.69-12.88 and OR = 2.58; CI, 1.19-5.58, respectively) for advanced disease. CONCLUSIONS. According to our results we hypothesize that the polymorphism in LEP gene may be relevant to PC risk and progression, supporting the hypothesis for leptin involvement in cancer ethiopathogenesis. (C) 2003 Wiley-Liss, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7