Orofacial genetics

Code:

EORTO 21

Acronym:

GENORO

Keywords
Classification	Keyword
OFICIAL	Dental Sciences

Instance: 2015/2016 - 2S

Active?	Yes
Responsible unit:	Curso de Especialização
Course/CS Responsible:	Specialization in Orthodontics

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
EORTO	4	Study Plan 2011/2012	2	-	1	9	27

Teaching language

Suitable for English-speaking students

Objectives

Providing competences that allow the recognition of genetic characteristics  and / or their inheritance patterns.

Provide knowledge to enable the identification of the main genetic syndromes with orofacial manifestations.

Enable students to interpret the results of genetic tests for craniofacial disorders.

Learning outcomes and competences

Managing competences to future orthodontic specialists to acquire skills to:

- Identify orofacial and craniofacial signs of genetic and hereditary disease,

- Request genetic testing to their patients,

- Interpret the results of genetic tests prescribed to their patients and be able to understand their clinical implications,

- Identify risk individuals.

Working method

Presencial

Program

1. Human Genome Organization.
Development, metabolism and homeostasis gene regulation.
Molecular evolution. Variation gene. individual susceptibilities and its growing importance.

2. Gene morphology . Gene concept.
DNA structure and human gene expression. DNA analysis. DNA to protein.
Structure of RNAs. RNA expression analysis.
 Salivary genetic testing - major salivary proteins and clinical implications.

3. Instability of the human genome. Mutations - etiology and types. Importance of mutations. Polymorphisms - etiology and types. Importance of polymorphisms. Mutations and repair mechanisms - Importance of pathology and susceptibility.
Genetic test for dentistry based on the detection of polymorphisms.

4. Orofacial genetics query.
The face and genetic diseases. detailed examination of the face. measuring the importance and standards for proper assessment of the relevant measures. Description and recognition of anomalies that may be observed in craniofacial structures. More relevant facial measurements.
Systematized approach to the observation of birth and / or genetic defects.

5. Cleft lip.

6. Syndromes orofacial with hypodontia.

7. Syndromes orofacial with hyperdontia teeth.

8. Syndromes orofacial with macrodontia and microdontia.

9. Syndromes orofacial with changes in the structure of the teeth (Amelogenesis imperfecta and dentinogenesis imperfecta).

10. Syndromes orofacial with craniosynostosis.

11. Syndromes with micrognathia.

12. Syndromes with mandibular prognathism.

13. Syndromes with altered facial height and facial asymmetry.

14. Heredity of malocclusion Angle class III.

Mandatory literature

Strachan T. Read AP; Human molecular genetics - Concepts and Applications. , 2009
Lewis Ricki; Human genetics
Gorlin RJ, Cohen MM JR, Levin LS, ed. ; Syndromes of the Head and Neck., 1990
Buyse ML, MD et al., ed. ; Birth Defects Encyclopedia.
Laskaris George; Color atlas of oral diseases in children and adolescents. ISBN: 0-86577-789-6
 Scully C, Welbury R, Flaitz C, Paes de Almeida O, ed. ; Orofacial health et disease in children and adolescents., 2002

Teaching methods and learning activities

Interactive presencial seminars.

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Description	Type	Time (hours)	Weight (%)	End date
	Participação presencial		75,00
	Trabalho prático ou de projeto		25,00
	Total:	-	100,00

Calculation formula of final grade

Evaluation formula: Seminars (75%) + Test Results (25%).