Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis

• Type: Article in International Scientific Journal
• Date: 2009

Authors

Silva, AM (Author) Other; Bettencourt, A (Author) Other; Pereira, C (Author) Other; Santos, E (Author) Other; Carvalho, C (Author) Other; Mendonca, D (Author) ICBAS; Costa, PP (Author) ICBAS; Monteiro, L (Author) Other; Martins, B (Author) Other

Journal

Title: Multiple Sclerosis Journal

Vol. 15

Pages: 771-774

ISSN: 1352-4585

Publisher: SAGE

Indexing

ISI Web of Knowledge - 16 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-003-JVH

DOI: 10.1177/1352458509104588

Abstract (EN): Background Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles has been described. Objectives We examined the influence of HLA-A*02 and HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression model. Conclusions DRB1*15 increased the risk of developing MS and HLA-A*02 decreased the risk. A*03 had no effect. To analyze if HLA-A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found. Multiple Sclerosis 2009; 15: 771-774. http://msj.sagepub.com

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4