Bone marrow contribution to the heart from development to adulthood

• Type: Another Publication in an International Scientific Journal
• Date: 2020

Authors

Sampaio Pinto, V (Author) Other; Ruiz Villalba, A (Author) Other; Nascimento, DS (Author) ICBAS; Pérez Pomares, JM (Author) Other

Journal

The Journal is awaiting validation by the Administrative Services.

Title: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vol. 112

Pages: 16-26

ISSN: 1084-9521

Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Indexing

Scopus - 1 Citation

Other information

Authenticus ID: P-00S-CER

DOI: 10.1016/j.semcdb.2020.06.008

Abstract (EN): Cardiac chamber walls contain large numbers of non-contractile interstitial cells, including fibroblasts, endothelial cells, pericytes and significant populations of blood lineage-derived cells. Blood cells first colonize heart tissues a few days before birth, although their recruitment from the bloodstream to the cardiac interstitium is continuous and extends throughout adult life. The bone marrow, as the major hematopoietic site of adult individuals, is in charge of renewing all circulating cell types, and it therefore plays a pivotal role in the incorporation of blood cells to the heart. Bone marrow-derived cells are instrumental to tissue homeostasis in the steady-state heart, and are major effectors in cardiac disease progression. This review will provide a comprehensive approach to bone marrow-derived blood cell functions in the heart, and discuss aspects related to hot topics in the cardiovascular field like cell-based heart regeneration strategies. © 2020 Elsevier Ltd

Language: English

Type (Professor's evaluation): Scientific