GWAS contribution to atrial fibrillation and atrial fibrillation-related stroke: pathophysiological implications

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Cruz, D (Author) Other; Pinto, R (Author) Other; Freitas Silva, M (Author) FMUP; José Pedro Nunes (Author) FMUP; Rui Medeiros (Author) ICBAS

Journal

Title: Pharmacogenomics

Vol. 20

Pages: 765-780

ISSN: 1462-2416

Publisher: ASHLEY PUBLICATIONS LTD

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00Q-YZ5

DOI: 10.2217/pgs-2019-0054

Abstract (EN): Atrial fibrillation (AF) and stroke are included in a group of complex traits that have been approached regarding of their study by susceptibility genetic determinants. Since 2007, several genome-wide association studies (GWAS) aiming to identify genetic variants modulating AF risk have been conducted. Thus, 11 GWAS have identified 26 SNPs (p <5x 10(-2)), of which 19 reached genome-wide significance (p <5x10(-8)). From those variants, seven were also associated with cardioembolic stroke and three reached genome-wide significance in stroke GWAS. These associations may shed a light on putative shared etiologic mechanisms between AF and cardioembolic stroke. Additionally, some of these identified variants have been incorporated in genetic risk scores in order to elucidate new approaches of stroke prediction, prevention and treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16