Late-Onset Asymmetric Myoclonus: An Emerging Syndrome

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Katschnig, P (Author) Other; João Massano (Author) FMUP; Edwards, MJ (Author) Other; Schwingenschuh, P (Author) Other; Cordivari, C (Author) Other; Bhatia, KP (Author) Other

Journal

Title: Movement Disorders

Vol. 26

Pages: 1744-1748

ISSN: 0885-3185

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 5 Citations

Other information

Authenticus ID: P-002-NZC

DOI: 10.1002/mds.23676

Abstract (EN): Background: Asymmetric cortical myoclonus is typically thought to be associated with either contralateral cortical structural lesions or degenerative disorders such as corticobasal degeneration when onset is in middle-aged or aged adults. This view has been challenged after a recent case series brought to light a syndrome of senile-onset, asymmetric cortical myoclonus not associated with any such identifiable disorders, thus, named "primary progressive myoclonus of aging." This is rare and no other reports have been published; hence, further such cases need to be highlighted. Case reports: Here, we describe 3 patients with some similarities, namely, adult-onset, asymmetric myoclonus that is most likely to be cortical, with an unremarkable thorough diagnostic workup, but with younger age at onset and longer follow-up time. Conclusions: This report expands on previous pheno-typical descriptions attempting to further develop and refine this possible diagnostic entity. (C) 2011 Movement Disorder Society

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5