Piperazine compounds as drugs of abuse

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Arbo, MD (Autor) Outra; Bastos, ML (Autor) FFUP; Carmo, HF (Autor) FFUP

Revista

Título: Drug and Alcohol Dependence

Vol. 122

Páginas: 174-185

ISSN: 0376-8716

Editora: Elsevier

Indexação

ISI Web of Knowledge - 52 Citações

Scopus - 74 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-ANZ

DOI: 10.1016/j.drugalcdep.2011.10.007

Abstract (EN): Synthetic drugs are among the most commonly abused drugs in the world. This abuse is widespread among young people, especially in the dance club and rave scenes. Over the last several years, piperazine derived drugs have appeared, mainly available via the internet, and sold as ecstasy pills or under the names of "Frenzy", "Bliss", "Charge", "Herbal ecstasy", "A2", "Legal X" and "Legal E". Although in the market piperazine designer drugs have the reputation of being safe, several experimental and epidemiological studies indicate risks for humans. Piperazine designer drugs can be divided into two classes, the benzylpiperazines such as N-benzylpiperazine (BZP) and its methylenedioxy analogue 1-(3,4-methylenedioxybenzyl)piperazine (MDBP), and the phenylpiperazines such as 1-(3-chlorophenyl)piperazine (mCPP), 1-(3-trifluoromethylphenyl)piperazine (TFMPP), and 1-(4-methoxyphenyl)piperazine (MeOPP). Toxicokinetic properties, including metabolic pathways, actions and effects in animals and humans, with some hypothesis of mechanism of action, and analytical approaches for the identification of these drugs are summarized in this review.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12