Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Carmo, H (Autor) FFUP; de Boer, D (Autor) Outra; Remiao, F (Autor) FFUP; Carvalho, F (Autor) FFUP; dos Reys, LA (Autor) Outra; Bastos, MD (Autor) FFUP

Revista

Título: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Vol. 811

Páginas: 143-152

ISSN: 1570-0232

Editora: Elsevier

Indexação

ISI Web of Knowledge - 30 Citações

Scopus - 33 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-7NZ

DOI: 10.1016/j.chromb.2004.08.026

Abstract (EN): 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10