A theory for bone resorption based on the local rupture of osteocytes cells connections: A finite element study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Ridha Hambli (Autor) Outra; Khalid H. Almitani (Autor) Outra; Abdessalem Chamekh (Autor) Outra; Hechmi Toumi (Autor) Outra; João Manuel R. S. Tavares (Autor) FEUP

Revista

Título: Mathematical Biosciences

Vol. 262

Páginas: 46-55

ISSN: 0025-5564

Editora: Elsevier

Indexação

ISI Web of Knowledge - 3 Citações

ISI Web of Science

Scopus - 10 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias

CORDIS: Ciências Tecnológicas

Outras Informações

ID Authenticus: P-00A-AHD

DOI: 10.1016/j.mbs.2015.01.005

Abstract (EN): In this work, a bone damage resorption finite element model based on the disruption of the inhibitory signal transmitted between osteocytes cells in bone due to damage accumulation is developed and discussed. A strain-based stimulus function coupled to a damage-dependent spatial function is proposed to represent the connection between two osteocytes embedded in the bone tissue. The signal is transmitted to the bone surface to activate bone resorption. The proposed model is based on the idea that the osteocyte signal reduction is not related to the reduction of the stimulus sensed locally by osteocytes due to damage, but to the difficulties for the signal in travelling along a disrupted area due to microcracks that can destroy connections of the intercellular network between osteocytes and bone-lining cells. To check the potential of the proposed model to predict the damage resorption process, two bone resorption mechano-regulation rules corresponding to two mechanotransduction approaches have been implemented and tested: (1) Bone resorption based on a coupled strain-damage stimulus function without ruptured osteocyte connections (NROC); and (2) Bone resorption based on a strain stimulus function with ruptured osteocyte connections (ROC). The comparison between the results obtained by both models, shows that the proposed model based on ruptured osteocytes connections predicts realistic results in conformity with previously published findings concerning the fatigue damage repair in bone.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10