Cerebrospinal fluid biomarkers: For the early diagnosis of Parkinson's disease [Biomarcadores no líquido cefalorraquidiano: Para o diagnóstico precoce de doença de Parkinson]

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2011

Autores

da Costa, AG (Autor) Outra; Gago, MF (Autor) Outra; Garrett, C (Autor) FMUP

Revista

Título: Acta Medica Portuguesa

Vol. 24 Nº 4

Páginas: 761-768

ISSN: 0870-399X

Editora: Ordem dos Medicos

Indexação

ISI Web of Knowledge

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-008-55M

Abstract (EN): In current medical practice, the diagnosis of Parkinson's disease remains essentially clinical. This practice determines that the diagnosis of Parkinson's disease is done in an already advanced neuropathological stage of the disease. The aim of this study is to review the validity of cerebrospinal fluid protein biological markers in the early diagnosis of Parkinson's disease. The ¿-synuclein and DJ-1 proteins, due to their role in the hereditary Parkinson's disease, have been the most widely studied cerebrospinal biomarkers. Nevertheless, they have had divergent results mostly owing to different processing, identification and control of laboratory techniques. The new proteomic techniques, directed to the detection of multiple undifferentiated proteins in cerebrospinal fluid (eg. ceruloplasmin, chromogranin B, apoH), are promising. The early diagnosis of Parkinson's disease is imperious as it is a progressive neurodegenerative disorder that causes extensive morbidity. Most of current scientific research in Parkinson's disease is focused on the discovery of neuroprotective drugs. Thus, the definition of biomarkers for the early diagnosis of Parkinson's disease is highly relevant.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8