Does timing and dosage of levodopa modify drug-induced dyskinesias and motor fluctuations? A retrospective analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Garrett, MC (Autor) FMUP; Rosas, MJ (Autor) Outra; Simoes, F (Autor) Outra; Vieira, S (Autor) Outra; Costa, M (Autor) Outra

Revista

Título: Parkinsonism and Related Disorders

Vol. 4

Páginas: 99-102

ISSN: 1353-8020

Editora: Elsevier

Indexação

ISI Web of Knowledge

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-007-84S

DOI: 10.1016/s1353-8020(98)00024-8

Abstract (EN): The aim of this study was to verify the influence of levodopa treatment in the development of long-term complications of Parkinson's disease (PD). We retrospectively analysed several epidemiological characteristics of the disease including long-term motor complications with timing and dose of levodopa in 50 patients. No differences between timing and initial dosage of levodopa were observed in patients who developed dyskinesias or motor fluctuations and those who did not. The patients who developed dyskinesias were younger and the rate of decline was faster in patients who developed motor fluctuations. These results suggest that late complications of levodopa are independent of the timing and initial dosage.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4