INCREASED CEREBROSPINAL-FLUID DOPAMINE AND 3,4-DIHYDROXYPHENYLACETIC ACID LEVELS IN HUNTINGTONS-DISEASE - EVIDENCE FOR AN OVERACTIVE DOPAMINERGIC BRAIN TRANSMISSION

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

GARRETT, MC (Autor) FMUP; SOARESDASILVA, P (Autor) Outra

Revista

Título: Journal of Neurochemistry

Vol. 58

Páginas: 101-106

ISSN: 0022-3042

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 21 Citações

Scopus - 22 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-Q3M

DOI: 10.1111/j.1471-4159.1992.tb09283.x

Abstract (EN): Levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), noradrenaline (NA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) in the CSF of patients with Huntington's disease (HD) were measured by HPLC. CSF DA, DOPAC, and MHPG levels were found to be increased in HD patients. Levels of HVA, 5-HIAA, and NA in the CSF of HD patients did not differ from those of controls. Changes in CSF DA and DOPAC levels were consistent with previous findings of increased DA tissue content in some brain areas of patients with HD. These results suggest that CSF DOPAC levels could be a more reliable index of overactive dopaminergic brain systems in HD than CSF HVA levels.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6