The Benefit of Bone Marrow Concentrate in Addition to a Glass-Reinforced Hydroxyapatite for Bone Regeneration: An In Vivo Ovine Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Joao Torres (Autor) Outra; Manuel Gutierres (Autor) Outra; Luis Atayde (Autor) Outra; Paulo Cortez (Autor) Outra; Maria Ascensão Lopes (Autor) FEUP; Santos, JD (Autor) FEUP; A. T. Cabral (Autor) Outra; Carola F. van Eck (Autor) Outra

Revista

Título: Journal of Orthopaedic Research

Vol. 35

Páginas: 1176-1182

ISSN: 0736-0266

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 4 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia médica

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia de biomateriais

Outras Informações

ID Authenticus: P-00P-JEY

DOI: 10.1002/jor.22800

Abstract (EN): This study evaluates the ability of a Glass Reinforced Hydroxyapatite Composite (GRHC), in a new microporous pellet formulation with autologous bone marrow concentrate (BMC), to enhance bone regeneration and new bone formation. Ninety non-critical sized bone defects were created in the femurs of nine Merino breed sheep and randomly left unfilled (group A), filled with GRHC pellets alone (group B) or filled with GRHC pellets combined with BMC (group C). The sheep were sacrificed at 3 weeks (three sheep), 6 weeks (three sheep) and 12 weeks (three sheep) and histological analysis (Light Microscopy-LM), scanning electron microscopy (SEM) and histomorphometric analysis (HM) were performed. At 3, 6, and 12 weeks, HM revealed an average percentage of new bone of 48, 72, 83%; 25, 73, 80%, and 16, 38, 78% for Groups C, B and A respectively (significantly different only at 3 weeks p<0.05). LM and SEM evaluation revealed earlier formation of well-organized mature lamellar bone in Group C. This study demonstrates that the addition of a bone marrow concentrate to a glass reinforced hydroxyapatite composite in a pellet formulation promotes early bone healing. (C) 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7