Drinking of Salvia officinalis tea increases CCl4-induced hepatotoxicity in mice

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Cristovao F Lima (Autor) Outra; Manuel Fernandes Ferreira (Autor) Outra; Cristina Pereira Wilson (Autor) Outra

Revista

Título: Food and Chemical Toxicology

Vol. 45 Nº 10

Páginas: 456-464

ISSN: 0278-6915

Editora: Elsevier

Indexação

ISI Web of Knowledge - 35 Citações

Scopus - 45 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-004-BET

DOI: 10.1016/j.fct.2006.09.009

Abstract (EN): In a previous study, the drinking of a Salvia officinalis tea (prepared as an infusion) for 14 days improved liver antioxidant status in mice and rats where, among other factors, an enhancement of glutathione-S-transferase (GST) activity was observed. Taking in consideration these effects, in the present study the potential protective effects of sage tea drinking against a situation of hepatotoxicity due to free radical formation, such as that caused by carbon tetrachloride (CCl4), were evaluated in mice of both genders. Contrary to what was expected, sage tea drinking significantly increased the CCl4-induced liver injury, as seen by increased plasma transaminase levels and histology liver damage. In accordance with the previous study, sage tea drinking enhanced significantly GST activity. Additionally, glutathione peroxidase was also significantly increased by sage tea drinking. Since CCl4 toxicity results from its bioactivation mainly by cytochrome P450 (CYP) 2E1, the expression level of this protein was measured by Western Blot. An increase in CYP 2E1 protein was observed which may explain, at least in part, the potentiation Of CCl4-induced hepatotoxicity conferred by sage tea drinking. The CCl4-induced hepatotoxicity was higher in females than males. In conclusion, our results indicate that, although sage tea did not have toxic effects of its own, herb-drug interactions are possible and may affect the efficacy and safety of concurrent medical therapy with drugs that are metabolized by phase I enzymes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9