Anticomplementary activity and constituents of Achillea ageratum L.

• Tipo: Artigo em Revista Científica Internacional
• Data: 1997

Autores

Vieira, LM (Autor) ICBAS; Nascimento, MSJ (Autor) FFUP; Pereira, J (Autor) Outra; Kijjoa, A (Autor) ICBAS

Revista

Título: Pharmaceutical and Pharmacological Letters

Vol. 7

Páginas: 131-134

ISSN: 0939-9488

Editora: Stuttgart Medpharm Scientific Publishers

Indexação

ISI Web of Knowledge

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-007-7CB

Abstract (EN): The methanol extract of Achillea ageratum L. has shown immunomodulatory activity on the classical pathway of the human complement system. Phytochemical investigation has resulted in the isolation of, besides ageratriol and a new germacrane derivative, 9-acetoxyageratriol, two flavones: 5,3',4'-trihydroxy-3,6,7-trimethoxyflavone and 5,4'-di-hydroxy-3,6,7-trimethoxyflavone. Ageratriol and the flavonoids have also been tested for modulation of the classical and alternative pathways of the complement system but showed negative results at concentrations used. The antioxidant activity of these compounds against a stable free radical, ¿,¿-diphenyl-ß-picrylhydrazyl, was also tested.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4