Control of individualized drug dosage regimens based on sparse measurements

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2000

Autores

Mendonca, T (Autor) FCUP; Lago, P (Autor) FCUP; Eusebio, D (Autor) Outra

Ata de Conferência Internacional

Título: MODELLING AND CONTROL IN BIOMEDICAL SYSTEMS 2000

Páginas: 273-277

4th IFAC Symposium on Modelling and Control in Biomedical Systems

KARLSBURG GREIFSWALD, GERMANY, MAR 30-APR 01, 2000

Indexação

ISI Web of Knowledge - 0 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia electrotécnica, electrónica e informática

Outras Informações

ID Authenticus: P-001-1X7

Abstract (EN): A number of different methods can be used for the design of individualized drug dosage regimens, based on measurements of the plasma concentration. This paper extends an adaptive control method coupled with Bayesian feedback to include all common routes and restrictions on the dosage regimens. Bolus administration and a piecewise constant administration (a model for the intravenous infusion) are both considered for pharmacokinetic systems of order n. Besides, a MATLAB package for the design of individualized drug dosage regimens was developed, both for clinical use and simulation purposes. The techniques are illustrated with the dosage of theophylline Copyright (C) 2000 IFAC.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5