Variation in STR loci of the human myelin basic protein gene: North Portugal and Sao Tome e Principe

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Pereira, L (Autor) Outra; Gusmao, L (Autor) FCUP; Prata, MJ (Autor) FCUP; Mota, P (Autor) Outra; Trovoada, MJ (Autor) Outra; Amorim, A (Autor) FCUP

Revista

Título: Human Biology

Vol. 72

Páginas: 481-487

ISSN: 0018-7143

Editora: Wayne State University Press

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-000-ZVE

Abstract (EN): Allele frequencies and a single-base substitution polymorphism for 3 short tandem repeat (STR) loci of the human myelin basic protein (MBP) gene were evaluated in North Portugal and Sao Tome e Principe, Strong linkage disequilibrium between loci MBPB and MBPC was found, However, the patterns of nonrandom allelic associations were very different in the 2 populations: levels of haplotypic diversity and heterozygosity were higher in the Sao Tome population. Similarly, a difference in the frequency of base substitution G --> A at position 124 was found: the frequency reached 4.1% in North Portugal and 0.5% in Sao Tome. In both populations it was always found to be associated with haplotypes B10/C11 and B12/C9.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7