MUC1 gene polymorphism in the gastric carcinogenesis pathway

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Silva, F (Autor) Outra; Carvalho, F (Autor) Outra; Peixoto, A (Autor) Outra; Seixas, M (Autor) Outra; Almeida, R (Autor) Outra; Carneiro, F (Autor) FMUP; Mesquita, P (Autor) Outra; Figueiredo, C (Autor) Outra; Nogueira, C (Autor) Outra; Swallow, DM (Autor) Outra; Amorim, A (Autor) FCUP; David, L (Autor) FMUP

Revista

Título: European Journal of Human Genetics

Vol. 9

Páginas: 548-552

ISSN: 1018-4813

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 59 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-000-V0V

DOI: 10.1038/sj.ejhg.5200677

Abstract (EN): MUC1 like most mucin genes shows extensive length polymorphism in the central core region. In a previous study it was shown that individuals with small MUC1 alleles/genotypes have an increased risk for development of gastric carcinoma. Our aim was to see if MUC1 gene polymorphism was involved in susceptibility for the development of conditions that precede gastric carcinoma: chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). We evaluated MUC1 polymorphism in a population of 174 individuals with chronic gastritis (CG) displaying (CAG) and/or intestinal metaplasia (IM). The population of patients with CG shows MUC1 allele frequencies significantly different from the gastric carcinoma patients and blood donors population. A significantly lower frequency of CAG and IM was observed in MUC1 VNTR heterozygotic patients. Within the group of patients with IM, MUC1 large VNTR homozygotes show a significantly higher frequency of complete IM while small, VNTR homozygotes show a significantly higher frequency of incomplete IM. These findings show that MUC1 polymorphism may define different susceptibility backgrounds for the development of conditions that precede gastric carcinoma: chronic atrophic gastritis (CAG) and intestinal metaplasia (IM).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5