Substructure of a Tunisian Berber Population as Inferred from 15 Autosomal Short Tandem Repeat Loci

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Houssein Khodjet El Khil (Autor) Outra; Karima Fadhlaoui Zid (Autor) Outra; Leonor Gusmao (Autor) Outra; Cintia Alves (Autor) Outra; Amel Benammar Elgaaied (Autor) Outra; Antonio Amorim (Autor) FCUP

Revista

Título: Human Biology

Vol. 80

Páginas: 435-448

ISSN: 0018-7143

Editora: Wayne State University Press

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 17 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-003-XA4

DOI: 10.3378/1534-6617-80.4.435

Abstract (EN): Currently, language and cultural practices are the only criteria to distinguish between Berber autochthonous Tunisian Populations. To evaluate these populations' possible genetic structure and differentiation, we have analyzed 15 autosomal short tandem repeat loci (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, TPOX, VWA, D2S1338, and D19S433) in three southern Tunisian Berber groups: Sened, Matmata, and Chenini-Douiret. The exact test of population differentiation based on allele frequencies at the 15 loci shows significant P values at 7 loci between Chenini-Douiret and both Sened and Matmata, whereas just 5 loci show significant P values between Sened and Matmata. Comparative analyses between the three Berber groups based on genetic distances show that P values for F(ST) distances are significant between the three Berber groups. Population analysis performed using Structure shows a clear differentiation between these Berber groups, with strong genetic isolation of Chenini-Douiret. These results confirm at the autosomal level the high degree of heterogeneity of Tunisian Berber populations that had been previously reported for uniparental markers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14