Evidence for population sub-structuring in Sao Tome e Principe as inferred from Y-chromosome STR analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Trovoada, MJ (Autor) Outra; Alves, C (Autor) Outra; Gusmao, L (Autor) Outra; Abade, A (Autor) Outra; Amorim, A (Autor) FCUP; Prata, MJ (Autor) FCUP

Revista

Título: Annals of Human Genetics

Vol. 65

Páginas: 271-283

ISSN: 0003-4800

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 20 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-000-VJG

DOI: 10.1046/j.1469-1809.2001.6530271.x

Abstract (EN): Seven Y-chromosome STR loci, DYS19, DPS389I, DYS389II, DYS390: DYS391, DYS392 and DYX393 have been analysed in population samples of Angolares, Forros and Tong as; three ethnic groups from the African archipelago of Sao Tome e Principe (Gulf of Guinea). Complete typings were obtained for 103 chromosomes, which belonged to 79 different haplotypes. The mean heterozygosity per locus in the overall Sao Tomean sample was 0.566, with the highest value found among Forros and the lowest among Angolares. Angolares also showed the lowest level of haplotype diversity. On average, the mean pairwise difference between two random haplotypes from Angolares, Forros and Tongas was 4.69, 6.74 and 6.23 repeats, respectively. The genetic distances were found to be statistically significant between Angolares and Forros or Tongas. In accordance, AMOVA revealed that the percentage of variation attributable to differences among groups was only significant when we distinguished between Angolares and non-Angolares. Globally, these results indicate that, with respect to the pool of male lineages of Sao Tome e Principe, some genetic sub-structuring does exist, basically determined by the Angolares ethnic group.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13