Human mtDNA haplogroups and reduced male fertility: real association or hidden population substructuring

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Pereira, L (Autor) Outra; Goncalves, J (Autor) Outra; Goios, A (Autor) Outra; Rocha, T (Autor) Outra; Amorim, A (Autor) FCUP

Revista

Título: International Journal of Andrology

Vol. 28

Páginas: 241-247

ISSN: 0105-6263

Editora: Blackwell

Indexação

ISI Web of Knowledge - 25 Citações

Scopus - 30 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-23V

DOI: 10.1111/j.1365-2605.2005.00539.x

Abstract (EN): A mitochondrial DNA (mtDNA) haplogroup association study carried out in 101 southern Portuguese males with oligozoospermia showed to be negative when comparing with a geographically matching control sample. Misleading positive association signs were however obtained when using other control samples from the same country. This shows that mtDNA population substructure can also introduce spurious signs in haplogroup association studies, as previously reported for Y-chromosome. However, our data do not exclude the probability that a particular mtDNA mutation contributes significantly to the reduction of sperm production, but indeed precludes the hypothesis of a significant association between such a mutation and specific haplogroup.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7