High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Teixeira, D (Autor) Outra; Vargens, D (Autor) Outra; Principe, A (Autor) Outra; Oliveira, E (Autor) Outra; Amorim, A (Autor) FCUP; Prata, MJ (Autor) FCUP; Suarez Kurtz, G (Autor) Outra

Revista

Título: Brazilian Journal of Medical and Biological Research

Vol. 43

Páginas: 677-680

ISSN: 0100-879X

Editora: Associacao Brasileira de Divulgacao Cientifica

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 3 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-003-531

DOI: 10.1590/s0100-879x2010007500056

Abstract (EN): A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the Sao Tome e Principe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3*A/*B polymorphism.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4