THE GLOMERULAR HYPERFILTRATION OF INSULIN-DEPENDENT DIABETES-MELLITUS MAY BE ASSOCIATED WITH ELEVATED PLASMA-LEVELS OF NORADRENALINE

• Tipo: Artigo em Revista Científica Internacional
• Data: 1988

Autores

CARVALHOBRAGA, D (Autor) Outra; NUNES, JP (Autor) FMUP; ALMEIDA, R (Autor) Outra; AMARAL, I (Autor) Outra; HARGREAVES, MP (Autor) Outra; POLONIA, J (Autor) FMUP

Revista

Título: Postgraduate Medical Journal

Vol. 64

Páginas: 31-33

ISSN: 0032-5473

Editora: BMJ PUBLISHING GROUP

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 2 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-TRA

Abstract (EN): To determine if adrenergic mechanisms can contribute to the glomerular hyperfiltration of early insulin-dependent diabetes mellitus (IDDM), we have studied plasma levels of noradrenaline (NA) and dopamine (DA) in eight normotensive, non-ketotic IDDM patients, with markedly elevated glomerular filtration rates, and in eight normal subjects as controls. NA was significantly higher in IDDM patients (median 414 pg/ml; range 260-1261) than in controls (251 pg/ml;range 118-465) (P < 0.05, Mann-Whitney U test). No significant differences could be found in DA levels. This study suggests that glomerular hyperfiltration of early IDDM is characterized by elevated plasma levels of NA, which may indicate an autoregulatory response to intrarenal haemodynamic abnormalities. However, the many differences, apart from glomerular filtration rate, between the patients and the control group selected make such an interpretation of our findings no more than tentative.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3