ENZYME-INHIBITION AS VISUALIZED WITH THE RESERVOIR MODEL - RELATIONSHIPS BETWEEN I-50 AND INHIBITION CONSTANT(S) OF AN ENZYME-INHIBITOR

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

ribeiro, jm (Autor) Outra; fontes, r (Autor) FMUP; sillero, a (Autor) Outra

Revista

Título: Computers in Biology and Medicine

Vol. 24

Páginas: 129-144

ISSN: 0010-4825

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-001-KAQ

DOI: 10.1016/0010-4825(94)90071-x

Abstract (EN): In the reservoir model, enzyme activity is simulated by holes in the wall of a reservoir (metabolic pool) containing liquid (substrate) at a certain level (concentration). The holes are computer drawn to reflect the kinetic properties of the enzyme, namely its maximum velocity (hole area) and K, (hole position). The model is here presented as a tool to intuitively visualize the effect of the different types of reversible enzyme inhibitors on the kinetic properties of an enzyme. The relationships between the concentration of an inhibitor producing 50% inhibition of an enzyme reaction (I-50) and its inhibition constant(s) are also discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16