Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap(6)A)

• Tipo: Artigo em Revista Científica Internacional
• Data: 1999

Autores

fontes, r (Autor) FMUP; sillero, mag (Autor) Outra; sillero, a (Autor) Outra

Revista

Título: Biochimie

Vol. 81

Páginas: 229-233

ISSN: 0300-9084

Editora: Elsevier

Indexação

ISI Web of Knowledge - 13 Citações

Scopus - 10 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-001-4XR

DOI: 10.1016/s0300-9084(99)80056-x

Abstract (EN): The synthesis of diadenosine hexaphosphate (Ap(6)A), a potent vasoconstrictor, is catalyzed by acyl-CoA synthetase from Pseudomonas fragi. In a first step AMP is transferred from ATP to tetrapolyphosphate (P-4) originating adenosine pentaphosphate (p(5)A) which, subsequently, is the acceptor of another AMP moiety from ATP generating diadenosine hexaphosphate (Ap(6)A). Diadenosine pentaphosphate (Ap(5)A) and diadenosine tetraphosphate (Ap(4)A) were also synthesized in the course of the reaction. In view of the variety of biological effects described for these compounds the potential capacity of synthesis of diadenosine polyphosphates by the mammalian acyl-CoA synthetases may be relevant, (C) Societe francaise de biochimie et biologic moleculaire / Elsevier, Paris.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5