Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis of Type 1 Cardio-Renal Syndrome in the General Ward

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

alvelos, m (Autor) Outra; pimentel, r (Autor) Outra; pinho, e (Autor) Outra; gomes, a (Autor) Outra; lourenco, p (Autor) Outra; teles, mj (Autor) Outra; almeida, p (Autor) Outra; guimaraes, jt (Autor) FMUP; bettencourt, p (Autor) FMUP

Revista

Título: Clinical journal of the American Society of Nephrology : CJASN

Vol. 6

Páginas: 476-481

ISSN: 1555-9041

Editora: American Society of Nephrology

Indexação

ISI Web of Knowledge - 82 Citações

Scopus - 83 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-TXJ

DOI: 10.2215/cjn.06140710

Abstract (EN): Background and objectives The early identification of acute heart failure (HF) patients with type 1 cardiorenal syndrome should be the first step for developing prevention and treatment strategies for these patients. This study aimed to assess the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in the early detection of type 1 cardio-renal syndrome in patients with acute HF. Design, setting, participants, & measurements One-hundred nineteen patients admitted with acute HF were studied. NGAL and creatinine were measured in the first hospitalization morning; creatinine was also measured at least after 48 to 72 hours. Physicians were blinded to NGAL and cystatin C levels. Type 1 cardio-renal syndrome was defined as an increase in the creatinine level of at least 0.3 mg/dl or 50% of basal creatinine. Results Type 1 cardio-renal syndrome developed within 48 to 72 hours in 14 patients (11.8%). Admission NGAL levels were higher in these patients: 212 versus 83 ng/dl. At a cutoff value of 170 ng/L, NGAL determined type 1 cardio-renal syndrome with a sensitivity of 100% and a specificity of 86.7%. The area under the receiver-operating characteristic curve of NGAL was 0.93 and that of cystatin C was 0.68. Conclusions Above a cutoff value of 170 ng/L, NGAL predicts 48- to 72-hour development of type 1 cardiorenal syndrome with a negative predictive value of 100% and a positive predictive value of 50%. NGAL independently associates with type 1 cardio-renal syndrome and might be a useful biomarker in the early recognition of these patients. Clin J Am Soc Nephrol 6: 476-481, 2011. doi: 10.2215/CJN.06140710

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6