Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Cesar Augusto Alvarenga (Autor) Outra; Jose Manuel Lopes (Autor) FMUP; Joao Vinagre (Autor) Outra; Paula Itagyba Paravidino (Autor) Outra; Marcelo Alvarenga (Autor) Outra; Adilson Prando (Autor) Outra; Lisias Nogueira Castilho (Autor) Outra; Paula Soares (Autor) FMUP; Athanase Billis (Autor) Outra

Revista

Título: Sao Paulo Medical Journal

Vol. 130

Páginas: 57-60

ISSN: 1516-3180

Editora: Associação Paulista de Medicina

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 8 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-H2S

DOI: 10.1590/s1516-31802012000100010

Abstract (EN): CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4