Core I gene is overexpressed in Hurthle and non-Hurthle cell microfollicular adenomas and follicular carcinomas of the thyroid

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Maximo, V (Autor) Outra; Preto, A (Autor) Outra; Crespo, A (Autor) Outra; Rocha, AS (Autor) Outra; Machado, JC (Autor) FMUP; Soares, P (Autor) FMUP; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: BMC Cancer

Vol. 4

ISSN: 1471-2407

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-B5F

DOI: 10.1186/1471-2407-4-12

Abstract (EN): Background: Most of the steps involved in the initiation and progression of Hurthle (oncocytic, oxyphilic) cell carcinomas of the thyroid remain unknown. Methods: Using differential display and semiquantitative RT-PCR we found, among other alterations, overexpression of the gene encoding the Core I subunit of the complex III of the mitochondrial respiratory chain in a follicular carcinoma composed of Hurthle cells. Results: Similar high levels of Core I gene expression were detected in nine follicular carcinomas (seven with Hurthle cell features), in seven microfollicular adenomas (one with Hurthle cell features) and in one micro/macrofollicular adenoma, in contrast to a lower/normal expression in nine papillary carcinomas (three with Hurthle cell features) and five macrofollicular adenomas (one of which displaying Hurthle cell features). No significative correlation was found between Core I overexpression and the proliferative activity of the lesions. Conclusions: We conclude that Core I overexpression in thyroid tumours is not associated with malignancy, Hurthle cells or proliferative activity. The pathogenetic mechanism linking Core I overexpression to the microfollicular pattern of growth of thyroid tumours remains to be clarified.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9