BRAF mutations are not a major event in post-Chernobyl childhood thyroid carcinomas

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Lima, J (Autor) Outra; Trovisco, V (Autor) Outra; Soares, P (Autor) FMUP; Maximo, V (Autor) Outra; Magalhaes, J (Autor) Outra; Salvatore, G (Autor) Outra; Santoro, M (Autor) Outra; Bogdanova, T (Autor) Outra; Tronko, M (Autor) Outra; Abrosimov, A (Autor) Outra; Jeremiah, S (Autor) Outra; Thomas, G (Autor) Outra; Williams, D (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: Journal of Clinical Endocrinology and Metabolism

Vol. 89

Páginas: 4267-4271

ISSN: 0021-972X

Editora: Endocrine Society

Indexação

ISI Web of Knowledge - 137 Citações

Scopus - 165 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-8SD

DOI: 10.1210/jc.2003-032224

Abstract (EN): The BRAF gene has been shown to be a major target for mutations in papillary thyroid carcinoma (PTC) ( 36 - 69%), which forms almost all of the over 2000 cases of thyroid carcinoma that have occurred in Chernobyl. BRAF is activated by point mutation, and were it to occur at a high frequency in Chernobyl-related tumors, it would challenge the dominant role of double-strand breaks in radiation-induced PTC. In a previous study, we detected the BRAF V600E mutation in 46% (23 of 50) of sporadic adult PTC. Using the same methodology, we have analyzed 34 post-Chernobyl PTC and detected RET/PTC rearrangements in 14 (41%) and BRAF mutations (V600E) in four 12%). These two alterations did not coexist in any PTCs. The mean age at exposure of patients with PTC showing BRAF mutation was higher than that of patients with tumors without BRAF mutation irrespective of their RET status. We have also analyzed 17 sporadic cases of childhood PTC and found that only one (6%) harbored the BRAF V600E mutation. We conclude that the frequency of BRAF mutations is significantly lower ( P = 0.0008) in post-Chernobyl PTC than in adult sporadic PTC, whereas no significant difference was found between post-Chernobyl and sporadic childhood PTCs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5