Should the use of inhibition of cholinesterases as a specific biomarker for organophosphate and carbamate pesticides be questioned?

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

guilhermino, l (Autor) ICBAS; barros, p (Autor) Outra; silva, mc (Autor) ICBAS; soares, amvm (Autor) Outra

Revista

Título: Biomarkers

Vol. 3

Páginas: 157-163

ISSN: 1354-750X

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 147 Citações

Scopus - 159 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-001-8AM

DOI: 10.1080/135475098231318

Abstract (EN): Recently there has been evidence that contaminants other than organophosphate and carbamate pesticides may inhibit the activity of the enzyme acetylcholinesterase (AChE) both under in vitro and in vivo conditions. In this study we investigated the in vitro effect of three detergents [dodecyl benzyl sulphonate (DBS), sodium dodecyl sulphate (SDS) and a mixture commonly used as domestic detergent (X)] and three metals [molybdenum, barium and chromium (VI)] on AChE activity of Mytilus galloprovincialis haemolymph. All the detergents tested significantly inhibited the activity of the enzyme. The lowest observed effect concentrations were equal to 12.5 for DBS and 50 mg l(-1) for SDS and X. Among the metals, molybdenum and barium had no effect on AChE activity, whereas chromium (VI) significantly depressed the activity of the enzyme at concentrations equal to or higher than 25 mg l(-1). These results suggest that the use of AChE as a specific biomarker for organophosphate and carbamate pesticides should be questioned and that the use of this enzyme as a biomarker could be extended.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7