Human serum alcaline phosphatase and ageing [Fosfátase alcalina sérica humana e envelhecimento]

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Negrao, MR (Autor) FMUP; Martins, MJ (Autor) FMUP; Ramos, E (Autor) Outra; Barros, H (Autor) FMUP; Hipolito Reis, C (Autor) Outra; Azevedo, I (Autor) Outra

Revista

Título: Acta Medica Portuguesa

Vol. 16 Nº 3

Páginas: 395-400

ISSN: 0870-399X

Editora: Ordem dos Medicos

Indexação

ISI Web of Knowledge

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-008-KHC

Abstract (EN): Background: In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. Objective: To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. Methods: Serum alkaline phosphatase was determined in a random sample of 203 community dwellers aged 40 or more years. Results: In men (n=87) total serum alkaline phosphatase markedly increased from the 5 th to the 6 th decade and then stabilized. For women (n=116) there was a slight increase in total serum alkaline phosphatase from the 5 th to the 6 th decade, followed by a bend upward after 69 years of age. There was a significant positive correlation between total serum alkaline phosphatase and age for the whole population. Conclusions: Serum alkaline phosphatase activity appears as a biomarker of age in humans, similarly to what has been described for experimental animal models.

Idioma: Português

Tipo (Avaliação Docente): Científica

Nº de páginas: 6