PROTECTIVE ROLE OF INTERFERON-GAMMA, TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-6 IN MYCOBACTERIUM-TUBERCULOSIS AND MYCOBACTERIUM-AVIUM INFECTIONS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

APPELBERG, R (Autor) ICBAS

Revista

Título: Immunobiology

Vol. 191

Páginas: 520-525

ISSN: 0171-2985

Editora: Elsevier

Indexação

ISI Web of Knowledge - 50 Citações

Scopus - 47 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-JH2

Abstract (EN): The screening of the cytokines that are involved in the control of mycobacterial infections in vivo may be used to select candidates for immunotherapeutical trials. We looked at the in vivo expression of different cytokines during Mycobacterium avium infection of mice and found a correlation between resistance and the level of expression of IFN-gamma and TNF-alpha. The use of specific neutralizing antibodies in vivo led to the identification of IFN-gamma and TNF-alpha as protective cytokines acting at the effector level of resistance to M. avium and M. tuberculosis. Furthermore, me found that IL-6 was involved in the induction of protective T cells in M. avium infections and that it was necessary to maintain sterilizing immunity in mice infected with M. tuberculosis. Regarding the antimycobacterial mechanisms of the macrophage against M. avium we found no role for oxygen or nitrogen reactive intermediates but rather the involvement of phagosomal acidification.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6