Interleukin-12 primes CD4(+) T cells for interferon-gamma production and protective immunity during Mycobacterium avium infection

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Silva, RA (Autor) Outra; Florido, M (Autor) Outra; Appelberg, R (Autor) ICBAS

Revista

Título: Immunology

Vol. 103

Páginas: 368-374

ISSN: 0019-2805

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 27 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-V2G

DOI: 10.1046/j.1365-2567.2001.01237.x

Abstract (EN): Interleukin-12 (IL-12) is a crucial cytokine for the generation of a protective immune response against Mycobacterium avium infection. In contrast to infected control mice, IL-12-deficient mice were unable to control bacterial proliferation and their spleen T cells were almost unresponsive in vitro to specific antigens of M. avium. Susceptibility of mice deficient in IL-12 was similar to that of interferon-gamma (IFN-gamma)-deficient mice. These data indicate a crucial role of IL-12 in the development of a T-cell population able to produce IFN-gamma and to mediate protection against M. avium infection. Treatment of M. avium-infected mice with IL-12 induced CD4(+) T cells with enhanced capacity to produce IFN-gamma as well as to confer increased protection against M/. avium.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7