CD40 is required for the optimal induction of protective immunity to Mycobacterium avium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Florido, M (Autor) Outra; Goncalves, AS (Autor) Outra; Gomes, MS (Autor) ICBAS; Appelberg, R (Autor) ICBAS

Revista

Título: Immunology

Vol. 111

Páginas: 323-327

ISSN: 0019-2805

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-BD1

DOI: 10.1111/j.1365-2567.2004.01812.x

Abstract (EN): C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40(-/-)) mice than in control mice. The increased susceptibility to infection of CD40(-/-) mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5