IMMUNOASSAY FOR TRANSTHYRETIN VARIANTS ASSOCIATED WITH AMYLOID NEUROPATHY

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

costa, pmp (Autor) ICBAS; teixeira, a (Autor) Outra; saraiva, mjm (Autor) ICBAS; costa, pp (Autor) Outra

Revista

Título: Scandinavian Journal of Immunology

Vol. 38

Páginas: 177-182

ISSN: 0300-9475

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 12 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-MVF

DOI: 10.1111/j.1365-3083.1993.tb01710.x

Abstract (EN): An anti-transthyretin (TTR) mouse monoclonal antibody (88.6.FD6) of IgG1 subclass, obtained using as immunogen TTR from the serum of a patient with familial amyloidotic polyneuropathy, was found to bind to sera from carriers of several amyloidogenic TTR variants associated with peripheral neuropathy, but not to normal sera or sera from carriers of non-pathogenic or cardiomyopathic variants, in an ELISA performed under special conditions. Further characterization suggests that it recognizes an epitope near the N-terminal side of the TTR monomer. We propose that this epitope is exposed in amyloid and could be implicated in fibril deposition in the peripheral nervous system.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6