Xanthohumol Modulates Inflammation, Oxidative Stress, and Angiogenesis in Type 1 Diabetic Rat Skin Wound Healing

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Raquel Costa (Autor) Outra; Rita Negrao (Autor) FMUP; Ines Valente (Autor) Outra; Angela Castela (Autor) Outra; Delfim Duarte (Autor) Outra; Luisa Guardao (Autor) Outra; Paulo J Magalhaes (Autor) Outra; Jose A Rodrigues (Autor) FCUP; Joao T Guimaraes (Autor) FMUP; Pedro Gomes (Autor) Outra; Raquel Soares (Autor) FMUP

Revista

Título: Journal of Natural Products

Vol. 76

Páginas: 2047-2053

ISSN: 0163-3864

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 64 Citações

Scopus - 67 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-006-JNQ

DOI: 10.1021/np4002898

Abstract (EN): Type 1 diabetes mellitus is responsible for metabolic dysfunction, accompanied by chronic inflammation, oxidative stress, and endothelium dysfunction, and is often associated with impaired wound healing. Phenol-rich food improves vascular function, contributing to diabetes prevention. This study has evaluated the effect of phenol-rich beverage consumption in diabetic rats on wound healing, through angiogenesis, inflammation, and oxidative stress modulation. A wound-healing assay was performed in streptozotocin-induced diabetic Wistar rats drinking water, 5% ethanol, and stout beer with and without 10 mg/L xanthohumol (1), for a five-week period. Wounded skin microvessel density was reduced to normal values upon consumption of 1 in diabetic rats, being accompanied by decreased serum VEGF-A and inflammatory markers (IL-1 beta, NO, N-acetylglucosaminidase). Systemic glutathione and kidney and liver H2O2, 3-nitrotyrosine, and protein carbonylation also decreased to healthy levels after treatment with 1, implying an improvement in oxidative stress status. These findings suggest that consumption of xanthohumol (1) by diabetic animals consistently decreases inflammation and oxidative stress, allowing neovascularization control and improving diabetic wound healing.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7