Increased circulating platelet microparticles as a potential biomarker in asthma

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

duarte, d (Autor) Outra; taveira-gomes, t (Autor) Outra; Sokhatska, O (Autor) FMUP; palmares, c (Autor) Outra; costa, r (Autor) Outra; negrao, r (Autor) FCNAUP; guimaraes, jt (Autor) FCNAUP; delgado, l (Autor) FMUP; soares, r (Autor) FCNAUP; moreira, a (Autor) FCNAUP

Revista

Título: Allergy: European Journal of Allergy and Clinical Immunology

Vol. 68

Páginas: 1073-1075

ISSN: 0105-4538

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 44 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-006-8HW

DOI: 10.1111/all.12190

Abstract (EN): Background: Endothelial (EMPs) and platelet microparticles (PMPs) have been studied as biomarkers in several inflammatory diseases and as central players in intercellular communication. Methods: In this cross-sectional study, we aimed to assess microparticle levels in asthma. Circulating microparticles and inflammatory and angiogenic markers were assessed by clinical and laboratorial evaluation, flow cytometry, and immunoassays, in a group of 20 asthmatic and 15 nonasthmatic subjects. Results: Circulating levels of PMPs (either CD31+/42b+ or CD31+/42b+/AnV+) were significantly increased in asthmatics (P=0.021) even after adjustment for confounders. Apoptotic EMPs (CD31+/42b--/AnV+) were significantly increased before (P=0.005) but not after adjustments (P=0.117). Conclusions: We propose that PMPs may be putative asthma biomarkers, playing a role in asthma pathophysiology.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3