Evaluation of an in vitro dissolution and permeation apparatus for oral solid pharmaceutical dosage forms

• Tipo: Artigo em Revista Científica Internacional
• Data: 1997

Autores

Ferreira, DC (Autor) FFUP; Costa, P (Autor) FFUP; Morgado, R (Autor) Outra; Lobo, JMS (Autor) Outra

Revista

Título: Drug Development and Industrial Pharmacy

Vol. 23

Páginas: 387-392

ISSN: 0363-9045

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-CBC

DOI: 10.3109/03639049709146141

Abstract (EN): An apparatus based in the USP dissolution test, the F-C-SL apparatus (Ferreira-Costa-Sousa Lobo), was developed that allowed the simultaneous evaluation of the in vitro release and permeation of oral solid pharmaceutical dosage forms. The release rate in both dissolution devices (USP and F-C-SL apparatus) was evaluated with acetaminophen tablets. Different test conditions (stirring rate and solvent volume ratio) were investigated and no significant differences in acetaminophen release rate were found between these apparatuses. In the F-C-SL apparatus, the in vitro permeation kinetics of acetaminophen were evaluated using synthetic membranes and followed a zero-order kinetic.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6