Lorazepam in the transdermal releasing system. Selection and study of plasticizers [LORAZEPAM EM SISTEMAS DE LIBERTACAO TRANSDERMICA - SELECCAO E ESTUDO DO PLASTIFICANTE]

• Tipo: Artigo em Revista Científica Internacional
• Data: 1995

Autores

Costa, P (Autor) FFUP; Ferreira, DC (Autor) FFUP; Sousa Lobo, JM (Autor) Outra

Revista

Título: Revista Portuguesa de Farmacia

Vol. 45

Páginas: 84-88

ISSN: 0484-811X

Editora: Ordem dos Farmaceuticos

Indexação

ISI Web of Knowledge

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-007-6JY

Abstract (EN): The aim of this work is to study the use of various substances used as plasticizers in lorazepam transdermal therapeutic systems (TTS). This work also involves the investigation of a series of concentrations of the best achieved plasticizer substance. The experimented substances were triethylcitrate, dioctyl phthalate, glycerin, polyethylene glycol 400 and polyethylene glycol 4000. Afterwards various concentration of triethylcitrate were tested (50%, 100%, 200%, 300% and 500% in relation towards the weight of lorazepam). The lyoavailability of lorazepam was determined in the TTS.

Idioma: Português

Tipo (Avaliação Docente): Científica

Nº de páginas: 5