Design and evaluation of a lorazepam transdermal delivery system

• Tipo: Artigo em Revista Científica Internacional
• Data: 1997

Autores

Costa, P (Autor) FFUP; Ferreira, DC (Autor) FFUP; Morgado, R (Autor) Outra; Lobo, JMS (Autor) Outra

Revista

Título: Drug Development and Industrial Pharmacy

Vol. 23

Páginas: 939-944

ISSN: 0363-9045

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 23 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-CBG

DOI: 10.3109/03639049709149144

Abstract (EN): The aim of this work was to study the release and the permeation rate of lorazepam, in order to develop a transdermal therapeutic system (TTS) containing that drug. Only a small number of drugs are by themselves able to permeate the skin at a useful rate in order to achieve a therapeutic effect. The lorazepam permeation rate did not reach that value and required a skin permeation enhancer to increase the skin's permeability. Three permeation enhancers (Tween 80, sodium lauryl sulfate, and benzalkonium chloride) were investigated in two different concentrations: 1% and 5% of the amount of lorazepam. The best permeation enhancement results were obtained using benzalkonium chloride in concentration of 5%.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6